Those animal characters which died under the hands of the humans are killed in different ways - poison, dying under animal abuse, put to sleep, shot by hunters, running over them with vehicles and other causes.
The notable humans who have killed the animal characters.
- Daisuke - victims: Mother Bear
- Hidetoshi - victims: John and Akame's substitutes, Akakabuto's minion, Tokimune (manga only) and a number of wild animals in his hunting days
- Takeda Gohei - victims: Akakabuto (partially) and other bears in his hunting days
- Shouji Sudou - victims: Hougen (manga only)
- Ninomiya - victims: Hybrid Polar Bear